Your Answer:  Persecution/Affliction

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Correct.

Jesus reminded his followers of the prophecies of Daniel and that they would suffer persecution for being saints...for being true followers and believers of Him.  Jesus also prophesied of the destruction of the temple of Jerusalem, the abomination of desolation (the terrible thing that causes destruction) and warned them to flee when they saw it coming:

And Jesus came out from the temple and was going away when His disciples came up to point out the temple buildings to Him. 2 And He answered and said to them, "Do you not see all these things? Truly I say to you, not one stone here shall be left upon another, which will not be torn down." 3 And as He was sitting on the Mount of Olives, the disciples came to Him privately, saying, "Tell us, when will these things be, and what will be the sign of Your coming, and of the end of the age?" Matthew 24:1-3 (NAS)

"Therefore when you see the abomination of desolation which was spoken of through Daniel the prophet, standing in the holy place (let the reader understand), 16then let those who are in Judea flee to the mountains;  Matthew 24:15-16 (NAS)

This warning was given by Jesus in ~A.D.30, several years prior to the Book of Revelation being written.

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